The ground shudders, and the putrid smell of rot fills your nostrils. The shadow of Erebos's Titan falls across you and your Irregulars. You raise your spear, and it radiates the light of the sun. The titan bellows ferociously. You charge forward anyway.
The strategy is still fairly simple: play your cards and attack. This duel does present the player with somewhat meaningful choices on turn 6 when you draw your fifth Plains, however, at which point you could play either of the two five-mana creatures in your hand. It's notable that the Titan has Lash of the Whip, which it will play after passing the turn with five mana up; that can deal with the double strike flyer, but not the Supply-Line Cranes.
Note that the two Damnations in the Titan's deck are the bottom two cards of its library, so they won't show up unless the player intentionally drags the game out. Also, the second one is irrelevant unless it hits a Banisher Priest that exiled a Grim Guardian or Fate Unraveler (the only way it can affect the player's life total), since the Titan will attempt to draw from an empty library before Kytheon.